genetics
Nazila Valatabar; Reza Safaralizadeh; Mohammadali Hosseinpour-Feizi
Volume 27, Issue 6 , January and February 2021, , Pages 770-775
Abstract
Introduction: Allergic rhinitis is a more prevalent health disorder in all regions of the world. In recent years, the study on Allergic rhinitis because of its higher prevalence and its effect on development of asthma have been more attended. In this article specifically reviews Singlenucleotide polymorphism ...
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Introduction: Allergic rhinitis is a more prevalent health disorder in all regions of the world. In recent years, the study on Allergic rhinitis because of its higher prevalence and its effect on development of asthma have been more attended. In this article specifically reviews Singlenucleotide polymorphism studies in allergic rhinitis disease.
Materials and Methods: In this study, the results of previous research conducted between 2005 and 2020 in the field of genetic susceptibility to allergic rhinitis have been used. Articles were collected by searching keywords Allergic rhinitis, genetic polymorphisms, single nucleotide polymorphism in the databases Scopus, Google Scholar, PubMed, Science Direct.
Results: In these studies, the candidate genes and the variants of single nucleotide polymorphism associated with allergic rhinitis have been investigated. The data collected in this study are the result of studies conducted in different parts of the world. The population of studies in these articles were allergic rhinitis patients.
Conclusion: Results showed association of several SNPs of various genes in allergic rhinitis that some of them may be useful incomprehension of AR pathophysiology finding new procedures for allergic rhinitis immunotherapy
genetics
Reyhaneh Ravanbakhsh Gavgani; Esmaeil Babaei; Mohammad Ali Hosseinpourfeizi; Vahid Montazeri
Volume 26, Issue 3 , September and October 2019, , Pages 285-292
Abstract
Introduction: Breast cancer is the most common tumor malignancy among women worldwide. Studies have revealed new class of RNA molecules named Long non-coding RNAs that play important role in tumor development, progression and metastasis. Therefore, this study aimed to evaluate long non-coding RNA lncUSMycN ...
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Introduction: Breast cancer is the most common tumor malignancy among women worldwide. Studies have revealed new class of RNA molecules named Long non-coding RNAs that play important role in tumor development, progression and metastasis. Therefore, this study aimed to evaluate long non-coding RNA lncUSMycN expression in breast cancer. Methods: In this study, 40 breast tumor with invasive ductal carcinoma and 40 normal marginal tissues were collected and after RNA extraction using TRizol kit, cDNA was synthesized. Expression level of lncUSMycN was obtained by applying qRT-PCR method. In order to evaluate association of lncUSMycN expression in tumor compared to normal tissues REST software was used. Biomarker potential of lncUSMycN was evaluated by drawing ROC curve using SigmaPlot. In addition, relationship between lncUSMycN expression and clinicopathological features was analysed. Results: Results from REST indicated significant upregulation of lncUSMycN in tumor tissues compared to normal marginal specimens (95% CI, p =0.001). ROC curve analysis demonstrated the biomarker potential of lncUSMycN (ROCAUC =0.72, p=0.0006). Evaluation of the relationship between lncUSMycN expression and clinicopathological features revealed that there are significant association between lncUSMycN expression and early stages (95% CI, P=0.005) and well-differentiated tumors (95% CI, P=0.046).Conclusion: Considering upregulation of lncUSMycN expression in invasive ductal carcinoma this lncRNA may be probably considered as a new potential diagnostic biomarker for breast cancer.
genetics
Sonia Faridi; Narges Zeinal zadeh
Volume 25, Issue 2 , May and June 2018, , Pages 259-269
Abstract
Background and objective: Breast cancer is one of the main causes of death among Iranian women. Human RAD51 protein, play a central role in homologous recombination repair of double-stranded DNA breaks and is essential for maintaining genomic stability. A single nucleotide polymorphism in the 5′-untranslated ...
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Background and objective: Breast cancer is one of the main causes of death among Iranian women. Human RAD51 protein, play a central role in homologous recombination repair of double-stranded DNA breaks and is essential for maintaining genomic stability. A single nucleotide polymorphism in the 5′-untranslated region of RAD51 gene (RAD51 135G˃C) is reported to modulate breast cancer risk. The aim of this study was to find out the relationship of this SNP with breast cancer risk among Iranian Azeri Turkish women.Materials and methods: This case-control study was performed on 127 breast cancer cases and 125 controls. Genomic DNA was extracted and the RAD51 135G > C genotype was determined using a PCR–Restriction Fragment Length Polymorphism (RFLP) based assay and confirmed by sequencing. The results were analyzed statistically. Results: The frequencies of CC, CG and GG genotypes of RAD51 135G˃C were 1.613%, 20.161% and 78.225% in control group and 2.362%, 24.409% and 73.228% in patients, respectively. The results showed no significant differences among patients and controls groups.Conclusion: The data presented here may suggest that the RAD51 135G > C polymorphism is not associated with breast cancer risk in Iranian Azeri population.